Do not eat large amounts of foods high in vitamin K. Vitamin K can make Coumadin less effective. Avoid eating cranberries, drinking cranberry juice, alcohol. Contraindications Pregnant women, patients with liver or kidney failure, acute arterial hypertension can't use Coumadin. Possible side effect Seek emergency medical help if any of these severe side effects occur: If you have questions about side effects, contact your doctor for medical advice. Drug interactions Coumadin can interact with certain herbal products, which can increase your risk of bleeding. It interacts with many commonly-used drugs: Tell your doctor about all medications you use including prescription, over-the-counter, vitamin, and herbal products.
Do not start a new medication without telling your doctor. Missed dose Take the missed dose as soon as possible. Skip the missed dose if it is time for your next scheduled dose. Don't take extra medicine to make up the missed dose. Overdose If you think you have overdosed the medicine seek emergency medical help at once. Overdose can cause excessive bleeding. Storage Store the medicine at room temperature away from light. Store it in a tight container. Note The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition.
Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. Warfarin can make you bleed more easily, especially if you have ever had: To make sure warfarin is safe for you, tell your doctor if you have ever had: It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take this medicine while you are breast-feeding a baby. How should I take warfarin? Take warfarin exactly as prescribed by your doctor.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take warfarin in larger or smaller amounts or for longer than your doctor tells you to. Take warfarin at the same time every day, with or without food. Never take a double dose. Warfarin can make it easier for you to bleed. You will need frequent "INR" or prothrombin time tests to measure your blood-clotting time and determine your warfarin dose. You must remain under the care of a doctor while taking this medicine. If you receive warfarin in a hospital, call or visit your doctor 3 to 7 days after you leave the hospital.
Your INR will need to be tested at that time. Do not miss any follow-up appointments. Tell your doctor if you are sick with diarrhea, fever, chills, or flu symptoms, or if your body weight changes. You may need to stop taking warfarin 5 to 7 days before having any surgery, dental work, or a medical procedure. Call your doctor for instructions. Wear a medical alert tag or carry an ID card stating that you take warfarin. Any medical care provider who treats you should know that you are taking this medicine. Store at room temperature away from heat, moisture, and light. Warfarin dosage information in more detail What happens if I miss a dose?
Avoid drinking alcohol. Ask your doctor before using any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen Advil, Motrin , naproxen Aleve , celecoxib Celebrex , diclofenac, indomethacin, meloxicam, and others. These medicines may affect blood clotting and may also increase your risk of stomach bleeding. Warfarin side effects Get emergency medical help if you have signs of an allergic reaction to warfarin: Warfarin increases your risk of bleeding, which can be severe or life-threatening. Call your doctor at once if you have any signs of bleeding such as: Clots formed by warfarin may block normal blood flow, which could lead to tissue death or amputation of the affected body part.
Get medical help at once if you have: Bleeding is the most common side effect of warfarin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Warfarin side effects in more detail What other drugs will affect warfarin? Many drugs including some over-the-counter medicines and herbal products can affect your INR and may increase the risk of bleeding if you take them with warfarin. Not all possible drug interactions are listed in this medication guide. It is very important to ask your doctor and pharmacist before you start or stop using any other medicine, especially: John's wort. This list is not complete and many other drugs can interact with warfarin.
This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Never take a double dose of this medication. Your doctor may occasionally change your dose to make sure you get the best results. Precautions Consult your doctor before taking any medicine for pain, arthritis, fever, or swelling. Do not eat large amounts of foods high in vitamin K. Vitamin K can make Coumadin less effective. Avoid eating cranberries, drinking cranberry juice, alcohol. Contraindications Pregnant women, patients with liver or kidney failure, acute arterial hypertension can't use Coumadin.
Possible side effect Seek emergency medical help if any of these severe side effects occur: Reversal of Coumadin anticoagulation may be obtained by discontinuing Coumadin therapy and, if necessary, by administration of oral or parenteral vitamin K1. The use of vitamin K1 reduces response to subsequent Coumadin therapy and patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged INR. Resumption of Coumadin administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment.
If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy. Prothrombin complex concentrate PCC , fresh frozen plasma, or activated Factor VII treatment may be considered if the requirement to reverse the effects of Coumadin is urgent. A risk of hepatitis and other viral diseases is associated with the use of blood products; PCC and activated Factor VII are also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to Coumadin overdosage. Crystalline warfarin sodium is an isopropanol clathrate.
Its empirical formula is C19H15NaO4, and its structural formula is represented by the following: Crystalline warfarin sodium occurs as a white, odorless, crystalline powder that is discolored by light. It is very soluble in water, freely soluble in alcohol, and very slightly soluble in chloroform and ether. Coumadin tablets for oral use also contain: All strengths: Lactose, starch, and magnesium stearate 1 mg: Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K-dependent clotting factors. Warfarin is thought to interfere with clotting factor synthesis by inhibition of the C1 subunit of vitamin K epoxide reductase VKORC1 enzyme complex, thereby reducing the regeneration of vitamin K1 epoxide [see Clinical Pharmacology 12.
Pharmacodynamics An anticoagulation effect generally occurs within 24 hours after warfarin administration. However, peak anticoagulant effect may be delayed 72 to 96 hours. The duration of action of a single dose of racemic warfarin is 2 to 5 days. The effects of Coumadin may become more pronounced as effects of daily maintenance doses overlap. This is consistent with the half-lives of the affected vitamin K-dependent clotting factors and anticoagulation proteins: Pharmacokinetics Coumadin is a racemic mixture of the R- and S-enantiomers of warfarin. The S-enantiomer exhibits 2 to 5 times more anticoagulant activity than the R-enantiomer in humans, but generally has a more rapid clearance.
Before taking this medicine You should not take Coumadin if you are allergic to warfarin, or if: You also should not take Coumadin if you are are prone to bleeding because of a medical condition, such as: Do not take Coumadin if you are pregnant, unless your doctor tells you to. Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. Coumadin can make you bleed more easily, especially if you have ever had: To make sure this medicine is safe for you, tell your doctor if you have ever had: It is not known whether warfarin passes into breast milk.
Watch for signs of bruising or bleeding in the baby if you take Coumadin while you are breast-feeding a baby. How should I take Coumadin? Take Coumadin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take warfarin in larger or smaller amounts or for longer than your doctor tells you to. Take this medicine at the same time every day, with or without food. Never take a double dose. Coumadin can make it easier for you to bleed. You will need frequent "INR" or prothrombin time tests to measure your blood-clotting time and determine your warfarin dose.
You must remain under the care of a doctor while taking Coumadin.
Compare prices, print coupons and get savings tips for Coumadin (Jantoven and Warfarin) and other Atrial Fibrillation, Heart Attack, Deep Vein Thrombosis, and Pulmonary Embolism drugs at CVS, Walgreens, and other pharmacies. Prices start at $ Coumadin is one of them and it is used for the similar way because thick blood may cause some sort of heart strokes and heart attack. In this problem there is a possibility of arteries disruption because of the clotting of the blood. In some of the precaution, it is recommended not to use this medicine if patient had bleeding problem in the. 3/17/ · Coumadin is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots. Coumadin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.. Coumadin may also be used for purposes not listed in this medication guide.
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