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While better-quality studies are needed to firmly establish its effectiveness as an antidepressant, there is some evidence for it helping in depression. Doses of around 200-300 mg per day seem to be fairly well-tolerated. It is generally safe and well-tolerated, although side effects can occur and there are concerns that it could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin. It can also be taken as a dietary supplement. SAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin so it could possibly play a role in depression.
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