The knee, ankle, and big toe joints are the most commonly affected. Gout is caused by high levels of uric acid in the blood. When uric acid levels become too high the uric acid can form hard crystals in your joints that cause pain. Colchicine works to decrease swelling and lessening the uric acid build up. Colcrys is also used to prevent pain attacks in the chest, joints, or abdomen caused by familial Mediterranean fever. Colchicine is not a medication that can be used to relieve other causes of pain. Only use Colchicine for these reasons if your doctor has specifically prescribed it this way. This medication can be used to reduce inflammation and swelling of the sac that covers the outside of your heart, this condition is called pericarditis.
How to Use Read the Medication Guide provided by your pharmacist before you start taking colchicine and each time you get a refill. If you have any questions regarding the information, ask your doctor or pharmacist. It takes away the pain and doesn't affect my heart. In addition it provides no side effects on me. In two words, I'm happy to have found Colchicine! A few months ago my doc prescribed me with Colchicine, it was a mere experiment as I had actually no hope it would work. But to my surprise the med turned to be very effective. I can now live without feeling constant pain in my elbows and my feet.
Sometimes my pain is so bad that I nearly faint. I used many different pain killers but they produce only short term effect as you can? My cousin advised me to try colchicine for the pain as this med helped him cope with the same problem. Next day my son ordered the med for me and I started taking it. The pain stopped almost immediately and the swelling decreased greatly. Now I have no problems with gout as I? I suffered from gout for 3 years or so and then I came across this med, don't actually remember how. But what matters most is that now there is no unbearable pain in my life! Product Origin: EU Turkey This product is able to be sourced and supplied at excellent prices because of favourable cross border currency conversions.
All products are authentic brand names and will include a product information insert in English. Medical Information: This product is able to be sourced and supplied at excellent prices because of favourable cross border currency conversions. This medication is used to treat gout. Colchicine, when used regularly, can help prevent a gout attack e. Though not a true pain reliever, colchicine relieves the pain that occurs with a gout attack. It is believed to act by decreasing the amount of swelling in the affected joint. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional.
Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used for other types of arthritis and certain liver conditions, and to prevent the aches and pains of a certain inherited disease familial Mediterranean fever. How to use Colchicine OralTake this medication by mouth exactly as directed by your doctor. When prescribed "as needed" to prevent a gout attack from becoming too painful, take 1 or 2 tablets, followed by 1 tablet every hour or 2 tablets every 2 hours, until the pain is gone or you have stomach upset or diarrhea.
Read about colchicine (Colcrys), a drug prescribed for the pain of acute gouty arthritis and FMF. Side effects, drug interactions, dosage, and preagnancy information is also included in the information. Save money on your medication with Colcrys Coupon. No registration required, say no monthly payments! Check Colchicine current price on May 23, > print a free RX24Drugs savings card > present it to your local pharmacy. Colchicine. Colchicine is an alkaloid of Colchicum autumnale L., Liliaceae as well as of many other species of the Liliaceae family. Colchicine has been used for many centuries in the treatment of gout and more recently as a general anti-inflammatory agent and in the treatment of Familial Mediterranean Fever.
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This product is able to be sourced and supplied at excellent prices because of favourable cross border currency conversions. This medication is used to treat gout. Colchicine, when used regularly, can help prevent a gout attack e. Though not a true pain reliever, colchicine relieves the pain that occurs with a gout attack. It is believed to act by decreasing the amount of swelling in the affected joint. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional.
Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used for other types of arthritis and certain liver conditions, and to prevent the aches and pains of a certain inherited disease familial Mediterranean fever. How to use Colchicine OralTake this medication by mouth exactly as directed by your doctor. When prescribed "as needed" to prevent a gout attack from becoming too painful, take 1 or 2 tablets, followed by 1 tablet every hour or 2 tablets every 2 hours, until the pain is gone or you have stomach upset or diarrhea. Colchicine controls pain best when taken at the first sign of a gout attack.
This "as needed" dosing should not be done more than every 3 days. To prevent or lessen the number of gout attacks per year, your doctor may direct you to take colchicine on a regular basis. Dosage will be based on your medical condition, the number of gout attacks you have per year, and your response to therapy. The maximum advised dose is 1. Ask your doctor about how soon you should repeat the treatment with the medication if you have another attack of gout. If you take this medication to prevent pain attacks caused by familial Mediterranean fever, the normal dosage is 1.
The total dose can be taken either once a day or divided into two daily doses. If you take more Colchicine than recommended it can increase your chances of side effects. You can buy Colchicine online with a legitimate prescription at a reduced cost compared to US pricing. Your Canada Drug Store will always supply you with high-quality medications at the best cost available. Buy Colchicine online as well as any other prescription medications you take from Your Canada Drug Store—the most secure choice for buying top quality and efficient drugs at an excellent price.
Here are a few advantages of purchasing your medications online with Your Canada Drug Store: Our 5 star commitment assures that you have access to the widest selection of the best brand and generic medicines. Dosage Forms and Strengths 0. Contraindications Patients with renal or hepatic impairment should not be given Colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4 inhibitors [See Drug Interactions 7 ]. Combining these dual inhibitors with Colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal Colchicine toxicity. Patients with both renal and hepatic impairment should not be given Colchicine capsules.
Warnings and Precautions Fatal Overdose Fatal overdoses, both accidental and intentional, have been reported in adults and children who have ingested Colchicine [See Overdosage 10 ]. Colchicine capsules should be kept out of the reach of children. Blood Dyscrasias Myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, and aplastic anemia have been reported with Colchicine used in therapeutic doses. Inhibition of both CYP3A4 and P-gp by dual inhibitors such as clarithromycin has been reported to produce life-threatening or fatal Colchicine toxicity due to significant increases in systemic Colchicine levels.
If avoidance is not possible, reduced daily dose should be considered and the patient should be monitored closely for Colchicine toxicity. Use of Colchicine capsules in conjunction with drugs that inhibit both P-gp and CYP3A4 is contraindicated in patients with renal or hepatic impairment [See Contraindications 4 ]. Neuromuscular Toxicity Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with Colchicine in therapeutic doses, especially in combination with other drugs known to cause this effect. Patients with impaired renal function and elderly patients even those with normal renal and hepatic function are at increased risk.
Once Colchicine treatment is ceased, the symptoms generally resolve within 1 week to several months. Adverse Reactions Gastrointestinal disorders are the most common adverse reactions with Colchicine. They are often the first signs of toxicity and may indicate that the Colchicine dose needs to be reduced or therapy stopped. These include diarrhea, nausea, vomiting, and abdominal pain. Colchicine has been reported to cause neuromuscular toxicity, which may present as muscle pain or weakness [See Warnings and Precautions 5. Toxic manifestations associated with Colchicine include myelosuppression, disseminated intravascular coagulation, and injury to cells in the renal, hepatic, circulatory, and central nervous system.
These most often occur with excessive accumulation or overdosage [See Overdosage 10 ]. The following reactions have been reported with Colchicine. These have been generally reversible by interrupting treatment or lowering the dose of Colchicine: Fatal drug interactions have been reported when Colchicine is administered with clarithromycin, a dual inhibitor of CYP3A4 and P-glycoprotein. Toxicities have also been reported when Colchicine is administered with inhibitors of CYP3A4 that may not be potent inhibitors of P-gp e. Patients with renal or hepatic impairment should not be given Colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4 [See Contraindications 4 ].
Combining these dual inhibitors with Colchicine capsules in patients with renal and hepatic impairment has resulted in life-threatening or fatal Colchicine toxicity. Physicians should ensure that patients are suitable candidates for treatment with Colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased Colchicine exposure due to drug interactions. Signs and symptoms of Colchicine toxicity should be evaluated promptly and, if toxicity is suspected, Colchicine capsules should be discontinued immediately. P-glycoprotein The concomitant use of Colchicine capsules and inhibitors of P-glycoprotein e. Complaints of muscle pain or weakness could be an indication to check serum creatinine kinase levels for signs of myopathy.
Colchicine can be administered with these drugs at the tested doses without a need for dose adjustment. However, these results should not be extrapolated to other co-administered drugs [See Drug-Drug Interactions 7. There are no adequate and well-controlled studies with Colchicine capsules in pregnant women. Colchicine crosses the human placenta. Developmental studies in animals were not conducted with Colchicine capsules, however published animal reproduction and development studies with Colchicine demonstrated embryofetal toxicity, teratogenicity, and altered postnatal development at exposures within or above the clinical therapeutic range.
Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Labor and Delivery The effect of Colchicine on labor and delivery is unknown. Limited information suggests that infants exclusively breastfed receive less than 10 percent of the maternal weight-adjusted dose. While there are no published reports of adverse effects in breast-feeding infants of mothers taking Colchicine, Colchicine can affect gastrointestinal cell renewal and permeability. Caution should be exercised and breastfeeding infants should be observed for adverse effects when Colchicine capsules is administered to a nursing woman. Pediatric Use Gout is rare in pediatric patients; the safety and effectiveness of Colchicine capsules in pediatric patients has not been evaluated in controlled studies.
Geriatric Use Because of the increased incidence of decreased renal function in the elderly population, and the higher incidence of other co-morbid conditions in the elderly population requiring the use of other medications, reducing the dosage of Colchicine when elderly patients are treated with Colchicine should be carefully considered.