Acute renal failure. Skin and Subcutaneous Tissue Disorders: Erythema multiforme, Stevens-Johnson syndrome. Mean Tmax and mean plasma elimination half-life of albendazole sulfoxide were unchanged. The pharmacokinetics of praziquantel were unchanged following co-administration with albendazole 400 mg. Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing. Theophylline Following a single dose of albendazole 400 mg , the pharmacokinetics of theophylline aminophylline 5. Albendazole induces cytochrome P450 1A in human hepatoma cells; therefore, it is recommended that plasma concentrations of theophylline be monitored during and after treatment.
There are no adequate and well-controlled studies of Albenza administration in pregnant women. Albenza should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Albenza should not be used in pregnant women except in clinical circumstances where no alternative management is appropriate. Obtain pregnancy test prior to prescribing Albenza to women of reproductive potential. Advise women of reproductive potential to use effective birth control for the duration of Albenza therapy and for one month after end of therapy.
If a patient becomes pregnant while taking this drug, Albenza should be discontinued immediately. If pregnancy occurs while taking this drug, the patient should be apprised of the potential hazard to the fetus. Albenza has been shown to be teratogenic to cause embryotoxicity and skeletal malformations in pregnant rats and rabbits. Nursing Mothers Albenza is excreted in animal milk. It is not known whether it is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Albenza is administered to a nursing woman.
Pediatric Use Hydatid disease is uncommon in infants and young children. In neurocysticercosis, the efficacy of Albenza in children appears to be similar to that in adults. Geriatric Use In patients aged 65 and older with either hydatid disease or neurocysticercosis, there was insufficient data to determine whether the safety and effectiveness of Albenza is different from that of younger patients. Patients with Impaired Renal Function The pharmacokinetics of Albenza in patients with impaired renal function has not been studied. Plasma concentrations of parent Albenza were measurable in only 1 of 5 patients. Overdosage In case of overdosage, symptomatic therapy and general supportive measures are recommended.
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To make sure Albenza is safe for you, tell your doctor if you have: It is not known whether this medicine will harm an unborn baby. Albenza should not be used during pregnancy, unless there is no alternate treatment. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 month after your treatment ends. It is not known whether albendazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
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