IUPAC name: S -2-amino-3- [4- 4-hydroxy-3,5-diiodophenoxy -3,5-diiodophenyl] propanoic acid Other names: Prescription only Molar mass: Description Levothyroxine sodium is a synthetic form of the natural thyroid hormone tetraiodothyronine T-4. Thyroid hormones are responsible for regulating the metabolic rate in the body, and play a vital role in the absorption of proteins, fats and carbohydrates. Levothyroxine sodium is used in medicine to treat hypothyroidism, a disease characterized by insufficient levels of natural thyroid hormone production. The disease has a number of symptoms, including energy loss, lethargy, weight gain, hair loss and changes in skin texture. Levothyroxine sodium is considered a slow-acting drug, and it may take 4-6 weeks to achieve full therapeutic effects.
The drug is the most commonly prescribed treatment for the thyroid gland in the world, and is considered the standard treatment for most cases of hypothyroidism. The action of levothyroxine sodium is very close to that of the popular thyroid drug Cytomel liothyronine sodium. Cytomel has a slightly different structure, and is a synthetic form of the thyroid hormone triiodothyronine T-3. In the body of a healthy person, there are sufficient levels of thyroid hormones T-3 and T-4. T-3 is considered the main active form of thyroid hormone, while T4 serves mainly as a reserve for T3, showing most of its metabolic activity through transformation in peripheral tissues to T3.
It is estimated that T3 has about four times more efficacy than T-4 in comparing milligrams per milligram. In addition, Cytomel is considered a more effective form of the drug for the treatment of the thyroid gland, both in its activity and in terms of side effects. Levothyroxine sodium is used by many athletes and bodybuilders for its ability to stimulate metabolism and support the breakdown of body fat reserves. The drug is usually taken with calorie restriction "drying" , when the user is interested in losing fat or increasing muscle relief.
It is assumed that the use of thyroid drugs may contribute to fat loss with a higher level of calorie intake than would be possible without the use of such drugs. Anabolic steroids are commonly used with these hormones, and many believe that the improved metabolism caused by these drugs can produce a rapid increase in muscle mass. However, the effectiveness of the drug in this regard has not yet been proven. Medical use of thyroxine T4 is usually used to treat hypothyroidism. Due to its ability to reduce the level of thyroid-stimulating hormone TSH , a hormone that, presumably, causes the development of goiter, the drug can also be used to treat goiter.
Story Levothyroxine sodium is the first commercial synthetic drug for the treatment of the thyroid gland in the United States, which was first marketed in 1955 under the name Synthroid from Flint Laboratory. The drug has a long history of therapeutic use in the United States and internationally, and for decades has been the most widely used drug for the treatment of hypothyroidism. In the community of bodybuilders and athletes, however, the faster and more powerful drug Cytomel liothyrosine sodium is more popular. Since Synthroid is considered a weaker delayed drug, you have to take it longer to achieve similar results.
The brand itself Synthroid has a long and complex history. A few years after its creation, Synthroid gained a monopoly in the market for levothyroxine sodium. In the 1980s, however, levothyroxine sodium generics began to appear. In response, in 1986, Flint funds research at the University of California. This was done to demonstrate that Synthroid has a higher therapeutic value than its generics. The study was completed in 1990, and, in fact, proved that generic drugs have equal effectiveness with Synthroid. The contract was a clause that for the publication of this study, you must obtain an approval from the company Flint. Began litigation for the publication.
Even after Flint's lab was sold to Boots, which was then sold to Knoll, the publication of the study was constantly postponed. Ultimately, the study was published in 1997. This was followed by a collective action claiming that the lack of information forced consumers to overpay 2-3 times only for the brand of the drug. As shipped Levothyroxine sodium is most often supplied in the form of oral tablets of 25, 50, 75, 100, 125, 150, 200 and 300 micrograms. Structural characteristics Levothyroxine sodium is a synthetic form of the thyroid hormone T4. It has the chemical designation L-3, 3 ', 5.
Warnings The FDA requires that all prescription lyothyronine sodium in the United States contain the following warning in the black box: In euthyroid patients, doses in the range of daily hormonal needs are not effective for weight loss. Taking larger doses can lead to serious and even life-threatening manifestations of toxicity, especially in combination with sympathomimetic amines anorexia drugs. Patients should avoid taking calcium and iron for 4 hours, as well as soy products for 3 hours after using the drug, as this may reduce the absorption of the drug. Grapefruit juice may delay absorption of Levothyroxine, but it does not significantly affect the bioavailability of the substance.
Other substances that reduce the absorption of L-Thyroxine include antacids containing aluminum and [[magnesium magnesium]], simethicone or sucralfate, cholestyramine, colestipol, Kayexalate. A study involving eight women showed that coffee may also have an effect on intestinal absorption of levothyroxine, although to a lesser extent than bran. Different substances can cause other side effects that can be very serious. Ketamine can lead to the development of hypertension and tachycardia, and tricyclic and tetracyclic antidepressants can increase the toxicity of the substance.
On the other hand, lithium can cause hyperthyroidism but more often hypothyroidism , affecting the iodine metabolism in the thyroid gland itself and, therefore, inhibiting synthetic levothyroxine. Side effects Side effects are usually associated with an overdose, and may include headache, irritability, nervousness, sweating, irregular heartbeat, increased intestinal motility, or menstrual disorders. Overdosing can also cause shock, as well as aggravate or cause angina pectoris or congestive heart failure. Chronic overdose of levothyroxine sodium causes symptoms usually associated with hyperthyroidism or overproduction of natural thyroid hormones in the body.
If such side effects occur, you should immediately reduce the dosage or stop taking levothyroxine sodium at all. Acute overdose can be life threatening. Application For the treatment of hypothyroidism from mild to moderate, the average replacement dose of levothyroxine sodium is about 1. At the beginning of therapy, a full therapeutic dose can also be applied, provided that the patient has no other diseases. It should be noted that, due to the long half-life of levothyroxine, the peak therapeutic effect with this dosage is reached after 4-6 weeks of use. When using not for its intended purpose to speed up the process of fat loss in bodybuilders and athletes, so that the body has enough time to adapt to changing levels of thyroid hormones, the dosage is usually increased gradually.
The drug usually starts with a low dose of 25-50 mcg, and gradually increases this amount by 25-50 mcg every day or two. The final dosage is usually in the range of 100-150 mcg, and rarely exceeds 250 mcg. It is important to remember that preparations for the thyroid gland are very powerful drugs and have significant potential for side effects. For caution, it is not recommended to use levothyroxine sodium in high doses and for more than eight weeks. In addition, at the end of each cycle it is usually recommended to also gradually reduce the dosage. Usually, this dosage is reduced by 25 MB every second or third day.
This is done to avoid sudden changes in hormone levels, which, otherwise, can cause side effects. It should be noted that, due to the slow action of levothyroxine sodium, complete elimination of the drug from the body may take several weeks or longer. Analogs L-thyroxine Common brand names for Levothyroxine include: There are also numerous generic versions of the drug. Counterfeit drugs are rare. How to take levothyroxine daily or weekly? The drug levothyroxine Synthroid, Levoxyl and others has long been used to treat hypothyroidism. In order for the tablets to be properly absorbed, it takes time, so usually patients are recommended to take them daily for an hour - half an hour before breakfast.
But such a regimen for some people may be inconvenient and not always respected. A new study suggests that the weekly dosage appears to be working. Indian scientists presented the results of the study at the annual meeting of the American Association of Clinical Endocrinologists 2016 in Orlando. Before Synthroid treatment can be started You will have to discuss all the aspects ofyour Synthroid treatment in advance with a qualified healthcare professional tomake sure the treatment is successful. Your doctor will be interested to knowabout any medical issues you have or used to have, including adrenal glanddisorder, anemia, problems with pituitary gland, heart disease, diabetes,coronary artery disease or a history of blood clots, and any other ones you thinkare important to mention and take into consideration.
In some cases, you willhave to get your dose of Synthroid adjusted for the conditions mention not to interferewith your successful treatment. How is Synthroid used? Make sure you keep taking Synthroid even if youdo not feel an improvement. You may need a few weeks to feel the first benefitsof Synthroid treatment. However, even when your symptoms improve, you may needto be taking Synthroid for the rest of your life, because your body will needthis hormone for proper functioning. The dose of Synthroid you have beenoriginally prescribed may have to be changed based on your doctor's assessment ofyour progress and your needs. Take every dose with a full glass of water,drinking the water really fast to make sure the tablet does not swell up andget stuck in your throat.
Other treatments that can interact withSynthroid Talk to your doctor if you are using amiodarone,ferrous sulfate iron supplement, calcium carbonate, sodium polystyrenesulfonate, antacids, lithium, sucralfate, cholesterol-lowering drugs orantidepressants, because they may cause interactions with your medicine. Overdose of Synthroid Never take too much of Synthroid, as thefollowing symptoms may occur: You will have toseek emergency medical help in case of Synthroid overdose, buy synthroid with no prescription australia. FDA category of Synthroid Synthroid is FDA A, which means it is not goingto harm your child no matter if you are pregnant or breastfeeding, order synthroid without prescription uk.
The only difference in the name. Manufacturers of generic drugs cannot use brand names for drugs, as it may be copyright infringement while use of known ingredients is absolutely legal. Tablets in blister packs containing 10 pills each. All teams under 60 pills are shipped in the package 1. Large orders can be split into two packs and come in 2 different envelopes. You should also have in mind several possible customs delays we are not responsible for. Thus why some parcels may arrive a bit later or earlier than expected. Delivery time can also depend on the country of destination. We do not sell any pharmaceutical products!
What Synthroid is for Synthroid is intended for the treatment of lowthyroid hormone, as well as prevention or treatment of enlarged thyroid gland,often caused by cancer, radiation treatment, surgery or hormonal imbalance of somekind. Synthroid is not supposed to be used for weight loss. You are supposed totalk to your doctor before starting to use Synthroid to find out any informationyou need to know for your treatment to be safe and successful. Patients withthyrotoxicosis or a history of a heart attack must never be taking Synthroid,as it is not safe for them. Before Synthroid treatment can be started You will have to discuss all the aspects ofyour Synthroid treatment in advance with a qualified healthcare professional tomake sure the treatment is successful.
Your doctor will be interested to knowabout any medical issues you have or used to have, including adrenal glanddisorder, anemia, problems with pituitary gland, heart disease, diabetes,coronary artery disease or a history of blood clots, and any other ones you thinkare important to mention and take into consideration. In some cases, you willhave to get your dose of Synthroid adjusted for the conditions mention not to interferewith your successful treatment. Indian scientists presented the results of the study at the annual meeting of the American Association of Clinical Endocrinologists 2016 in Orlando. New research echoes some of the findings of previous studies.
American endocrinologists, who reviewed the results, said that in general, they still prefer daily dosage. In the new study, 40 women participated, aged 25 to 55 years with a diagnosis of hypothyroidism, which they had for at least five years, and they were on a daily dose of levothyroxine. They were divided into two groups. One group included women who had a normal level of thyroid stimulating hormone TSH at the beginning of the study; in another group - whose level was above the normal range elevated TSH level indicates an insufficiently active thyroid gland. In both groups of women, for six months, once a week, they took a dose of levothyroxine seven times their daily dose.
In the 1st group, with a TSH level close to ideal at the beginning of the study, the normal functioning of the thyroid gland was maintained for 6 months. In the second group, 16 out of 20 also had normal functioning for 16 weeks. By the age of six months, the rates had reached 18. Two did not achieve normal thyroid function, possibly due to diabetes and obesity, the researchers said. The researchers claim that the weekly regimen is effective and safe, making it a possible alternative to daily therapy. They also came to the conclusion that the weekly schedule, "can be considered as the first line of therapy when working with young and middle-aged women, faced with impaired absorption due to early breakfast.
They should take a weekly dose on an empty stomach, and skip the remaining six days. The "half-life" of the thyroid hormone how long it stays in your system means that if you give it daily there are minimal highs and lows highs and lows of its blood level, "she says. This means that the patient may have symptoms of too much thyroid hormone immediately after the dose and symptoms of too little before the next dose. This is not an ideal at all. High levels can potentially be associated with risks such as fast or irregular heartbeat. While the study as a whole showed that patients were fine, he would not recommend it for people with heart disease.
Recalling the daily dose is easy, says Dr. Neydo, MD, if the patient holds the medicine next to the bed. Then you can go in for the usual morning procedures before breakfast while the medicine is absorbed. Jonklaas, adding that the medicine can be taken both morning and evening. I think working on finding a suitable schedule that you could stick to is much preferable to weekly therapy. I am also concerned that this is not suitable for women of childbearing age. Current guidelines issued by the American Thyroid Association say that weekly dosage can be considered if the patient has problems with adherence to treatment. Thyroid gland: Your weight increases, and the image of the food remained the same?
Do you often feel chills? Do you have hair loss, sweating? Often feel anxiety, explode on trifles? All the fault may be dysfunction of the thyroid gland. Hypothyroidism is a general condition of the body caused by a deficiency of thyroid hormones, which is more common in women. It is difficult to diagnose it, since the disease is almost asymptomatic. Often, when we feel drowsiness, lethargy, pain in the joints, we blame everything on avitaminosis or overwork. Thyroid hormones affect the work of absolutely all organs, so it is important to identify the problem in a timely manner and begin treatment by an endocrinologist.
Symptoms of thyroid disease 1. Depression and depression Insufficient production of thyroid hormones often causes depression, apathy and depression due to the fact that these hormones are directly related to the production of serotonin in the brain. At the same time, an excess of thyroid hormones makes us aggressive, irritable and anxious. Constipation One of the most common symptoms of hypothyroidism. Malfunctions of the thyroid gland lead to indigestion and constipation. Patients also complain of belching and heaviness in the stomach.
Drowsiness A person with hypothyroidism can sleep 12 hours a day for several days in a row, but still feel tired. Constant morning lethargy and drowsiness are very disturbing signals. Hair loss and dry skin Due to the slow metabolism caused by hormonal imbalances, hair and skin do not receive adequate nutrition. This leads to a deterioration of their condition. Dull eyes, pale skin with a yellowish tinge - a portrait of a patient with hypothyroidism. Unreasonable weight gain A sudden increase in weight without any reason is a very important symptom. At the same time, all efforts to reduce body weight are unsuccessful. Decreased libido Insufficient thyroid function also affects hormone production, which is responsible for sexual desire.
Muscle pain, convulsions A small amount of thyroid hormones can damage nerves, which send signals from the brain to the rest of the body.
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